The auto update statistics option, the auto create statistics option, and the Parallelism setting are turned off in the SQL Server 2000 or SQL Server 2005 database instance that hosts the BizTalk Server 2004 or BizTalk Server 2006 BizTalkMsgBoxDB database
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Source: Knowledge Base
Product: Microsoft SQL Server 2005 Enterprise Edition, SQL Server 2005 Enterprise X64 Edition
& SQL Server 2005 Standard Edition
Notification Contents: New and Major Modifications
The auto update statistics option, the auto create statistics option, and the Parallelism setting are turned off in the SQL Server 2000 or SQL Server 2005 database instance that hosts the BizTalk Server 2004 or BizTalk Server 2006 BizTalkMsgBoxDB database
http://support.microsoft.com/kb/912262/en-US